Spinosad's widespread commercial launch was deferred, awaiting final MRL or tolerance approvals in a few remain… Important: The information below refers to products available in the United States that contain spinosad. 2 Spinosad is an aerobic fermentation product of the soil bacterium, ... 32 Chemical Names: The name spinosad is derived from 33 combining the characters from spinosyn A and spinosyn 34 D. The material is a mixture of about 85% Spinosyn A ... 51 Trade Names: Tracer, Success, Conserve, Spintor. The generic name of Natroba is spinosad. Fire Ants, spider mites, and reproductive toxins… CAS number: 168316-95-8 . … [2], Spinosad is sold under the trade names, Comfortis, Trifexis, and Natroba. [5] Two other uses for spinosad are for pets and humans. 52 … How the information is presented. [2] It kills insects by hyperexcitation of the insect nervous system. [7], Spinosad has high efficacy, a broad insect pest spectrum, low mammalian toxicity, and a good environmental profile, a unique feature of the insecticide compared to others currently used for the protection of grain products. When do Natroba patents expire, and what generic alternatives are available? [5] Its overall protective effect varies with insect species and life stage. Example home, garden or landscape use products 6. Therapeutic effects Eradication of head lice. [3], Spinosad is a novel mode-of-action insecticide derived from a family of natural products obtained by fermentation of S. spinosa. Information about pesticides used in urban situations. Excipient information presented when available (limited, particularly for generics); consult specific product labeling. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. These include thrips, leafminers, spider mites, mosquitoes, ants, fruit flies and others. Techincal Name Trade Name Manfacturer / Distributor General Code for Pesticide Formulation a.i. Chemical formula: C83H132N2O20Drugbank ID: DB08823. [8] Its labeled use rate is set at 1 ppm (1 mg a.i./kg of grain) and its maximum residue limit (MRL) or tolerance is set at 1.5 ppm. The product's dosage form is suspension and is administered via topical form. Drug class (es): topical anti-infectives. Brand names: Natroba. Spinosad is a natural substance made by a soil bacterium that can be toxic to insects. [8] It was first registered as a pesticide in the United States for use on crops in 1997. SC […] Spinosad is a macrocyclic lactone and therefore should in theory be contraindicated for use on dogs with the MDR-1 mutation (see Chapter 5: Vulnerable Patients). supplier Spinosad 168316-95-8. Trade Name: Antixx Liquid Ant Bait Active Ingredient: Spinosad Supplier Info: W. Neudorff GmbH KG An der Muhle 3 Emmerthal 31860 Germany Office 250-652-5888 Labels: [5] The mode of action of spinosoid insecticides is by a neural mechanism. Spinosad was obtained from Dow Agro Sciences (Indianapolis, IN), and the pyrethrins was from McLaughlin Gormley King (Minneapolis, MN). [9][10] Trifexis also includes milbemycin oxime. [1], Spinosad is highly active, by both contact and ingestion, in numerous insect species. It is used to control a wide variety of pests. Trade name: Tracer® Common name: Spinosad 24% Suspension Concentrate (SC). [7], Spinosad has been used around the world for the control of a variety of insect pests, including Lepidoptera, Diptera, Thysanoptera, Coleoptera, Orthoptera, and Hymenoptera, and many others. spinosad topical. Its chemical name is Spinosyn A where as its molecular formula is … nov. Isolated from soil Collected in a Sugar Mill Rum Still", 10.1002/1526-4998(200102)57:2<177::AID-PS281>3.0.CO;2-Z, "Spinosad: A new natural product for stored grain protection", "Resistance and cross-resistance to the spinosyns- A review and analysis", "Safer Flea Control | Insects in the City", "Codling Moth and Leafroller Control Using Chemicals", "Spinosad Insecticide: Subchronic and Chronic Toxicity and Lack of Carcinogenicity in CD-1 Mice", "Spinosad Insecticide: Subchronic and Chronic Toxicity and Lack of Carcinogenicity in Fischer 344 Rats", https://en.wikipedia.org/w/index.php?title=Spinosad&oldid=998542987, Chemical articles with multiple compound IDs, Multiple chemicals in an infobox that need indexing, Chemical articles with multiple CAS registry numbers, Chemical articles with multiple PubChem CIDs, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Wikipedia articles needing clarification from June 2014, Creative Commons Attribution-ShareAlike License, This page was last edited on 5 January 2021, at 21:34. Because spinosad is a relatively new compound, it's not yet found its way onto many garden store shelves. - Related authorised biocidal products (trade name of a biocidal product). Attracts and kills insects feeding on or near the base of plants. It is a mixture of two chemicals called spinosyn A and spinosyn D. It is used to control a wide variety of pests. Comfortis and Trifexis brands treat adult fleas on pets; the latter also prevents heartworm disease. US Brand Name. Some of these products are approved for use in organic agriculture. Product-type: PT18. There are two patents protecting this drug. Pyriproxyfen has low acute toxicity. The bacteria produce yellowish-pink aerial hyphae, with bead-like chains of spores enclosed in a characteristic hairy sheath. Uses. Spread the knowledgeHi all, I have collected a list of all the major insecticides available in the market and arranged them in a learn-able organized tabular form. Spinosyns occur in over 20 natural forms, and over 200 synthetic forms (spinosoids) have been produced in the lab. Tradename (spinosad) Suspension, 0.9% was demonstrated to be statistically superior to an active comparator NIX (permethrin 1%) in each of two well-controlled pivotal, Phase 3 trials. Conserve SC Spinosad/spintor Spinosyn A and Spinosyn D 5 Dow AgroSciences Coragen Chlorantraniliprole 3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide 28 Dupont Co-Ral Coumaphos O,O-diethyl O-(3-chloro-4-methyl-2-oxo2H-1-enzopyuran 7-yl- phosphorothioate 1B Bayer Corporation The trade names and general application rates of each biopesticide are given in Table 1. Spinosad controls a wide variety of pests including fleas, caterpillars, fruit flies, spider mites, fire ants, leaf beetle larvae, thrips, leaf miners and leaf beetle larvae to name only a few.It is recommended as one component of Integrated Pest Management for greenhouses because it does not target beneficial insects such as ladybugs and predatory mites. Look for spinosad under the following trade names: Monterey Garden Insect SprayR, Ferti-lomeR Borer, Bagworm, Leafminer & Tent Caterpillar Spray, and Bulls-EyeTM Bioinsecticide. Spinosad is a mixture of spinosyn A and spinosyn D. Chemical name ... Trade names: Success, Tracer, Spintor, Spinoace, Boomerang, Laser, Extinosad Structural formula: Spinosyn A O O O O O H H H H H CH 3 O CH 3 O CH CH 3O 3 OCH 3 CH 3 2 (CH 3) 2N OCH 3. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. [2] Spinosad so far has proven not to cause cross-resistance to any other known insecticide. It affects certain species only in the adult stage, but can affect other species at more than one life stage. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. [2] Spinosad is relatively nonpolar and not easily dissolved in water. Available for Android and iOS devices. Ecotoxicology parameters have been reported for spinosad, and are:[14], Chronic exposure studies failed to induce tumor formation in rats and mice; mice given up to 51 mg/kg/day for 18 months resulted in no tumor formation. Bio-insecticides: A. The tri-O-methylrhamnose at the 9-position of the 17-pseudoaglycone of spinosyn A was hydrolyzed under more vigorous acidic conditions to give the aglycone of spinosyn A. [6] Spinosyn A resembles a GABA antagonist and is comparable to the effect of avermectin on insect neurons. [16], InChI=1S/C42H67NO10.C41H65NO10/c1-11-26-13-12-14-35(53-37-16-15-34(43(6)7)24(4)49-37)23(3)38(45)33-20-31-29(32(33)21-36(44)51-26)17-22(2)28-18-27(19-30(28)31)52-42-41(48-10)40(47-9)39(46-8)25(5)50-42;1-10-26-12-11-13-34(52-36-17-16-33(42(5)6)23(3)48-36)22(2)37(44)32-20-30-28(31(32)21-35(43)50-26)15-14-25-18-27(19-29(25)30)51-41-40(47-9)39(46-8)38(45-7)24(4)49-41/h17,20,23-32,34-35,37,39-42H,11-16,18-19,21H2,1-10H3;14-15,20,22-31,33-34,36,38-41H,10-13,16-19,21H2,1-9H3/t23-,24-,25+,26+,27-,28+,29-,30-,31-,32+,34+,35+,37+,39+,40-,41-,42+;22-,23-,24+,25-,26+,27-,28-,29-,30-,31+,33+,34+,36+,38+,39-,40-,41+/m11/s1, (A): InChI=1/C42H67NO10.C41H65NO10/c1-11-26-13-12-14-35(53-37-16-15-34(43(6)7)24(4)49-37)23(3)38(45)33-20-31-29(32(33)21-36(44)51-26)17-22(2)28-18-27(19-30(28)31)52-42-41(48-10)40(47-9)39(46-8)25(5)50-42;1-10-26-12-11-13-34(52-36-17-16-33(42(5)6)23(3)48-36)22(2)37(44)32-20-30-28(31(32)21-35(43)50-26)15-14-25-18-27(19-29(25)30)51-41-40(47-9)39(46-8)38(45-7)24(4)49-41/h17,20,23-32,34-35,37,39-42H,11-16,18-19,21H2,1-10H3;14-15,20,22-31,33-34,36,38-41H,10-13,16-19,21H2,1-9H3/t23-,24-,25+,26+,27-,28+,29-,30-,31-,32+,34+,35+,37+,39+,40-,41-,42+;22-,23-,24+,25-,26+,27-,28-,29-,30-,31+,33+,34+,36+,38+,39-,40-,41+/m11/s1, Except where otherwise noted, data are given for materials in their, The non‐target impact of spinosyns on beneficial arthropods, Spinosad toxicity to pollinators and associated risk, "Saccharopolyspora spinosa sp. It is considered a natural product, thus is approved for use in organic agriculture by numerous nations. [7] Spinosyn A is slow to penetrate to the internal fluids of larvae; it is also poorly metabolized once it enters the insect. Spinosad has been used around the world for the control of a variety of insect pests, including Lepidoptera, Diptera, Thysanoptera, Coleoptera, Orthoptera, and Hymenoptera, and many others. The species subject to very high rates of mortality as larvae, but not as adults, may gradually be controlled through sustained larval mortality. Suspension, External: Natroba: 0.9% (120 mL) [contains benzyl alcohol, cetearyl alcohol, fd&c yellow #6 (sunset yellow), isopropyl alcohol, propylene glycol] Generic: 0.9% (120 mL) Natroba is sold for treatment of human head lice. Substance name: Spinosad. TRACER is an suspension concentrate formulation with 480 g ai.L-1, while LASER is an aqueous suspension emulsion in oil with 125 g ai.L-1. The results table presents information on an active substance, such as approval start and end date, evaluating competent authority and approval or assessment status. Natroba; Descriptions. SPINOSAD (203) IDENTITY ... ISO common name: spinosad. In the US, pyriproxyfen is often marketed under the trade name Nylar. Spinosad topical is used in the treatment of: Head Lice. This drug has forty-eight patent family members in thirty countries. Lice. In Europe, pyriproxyfen is known under the brand names Cyclio and Exil Flea Free TwinSpot (Emax). The active ingredient in Entrust SC Naturalyte is spinosad. Several spinosad formulations under the trade name Natular, ranging from fast release emulsifiable concentrate and granules to slow release tablets and briquets, have been registered for mosquito control in the United States and elsewhere (Clarke, Roselle, IL). NDC Product Information Natroba with NDC 52246-929 is a a human prescription drug product labeled by Parapro Llc. Spinosad is an outstanding pesticide used in agriculture to control over pest and for increase the production. [1] This genus is defined as aerobic, Gram-positive, nonacid-fast actinomycetes with fragmenting substrate mycelium. [4] Spinosyn A is highly active against neonate larvae of the tobacco budworm, Heliothis virescens, and is slightly more biologically active than spinosyn D. In general, spinosyns possessing a methyl group at C6 (spinosyn D-related analogs) tend to be more active and less affected by changes in the rest of the molecule. Class : Common Name : Trade Name-----I piperonyl butoxide Butacide, Incite I potassium salts Safer Insecticidal Soap F potassium bicarbonate Kaligreen Min.Order: 1 Kilogram FOB Price: USD $ 1.0-3.0/Kilogram hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and developm S.No. Tracer is comprised primarily of two macrocyclic lactones, Spinosyn A and D, secondary metabolites produced by the actinomycete, Saccharopolyspra spinosa under natural fermentation condition. Spinosad has recently been used in oral preparations (as Comfortis) to treat C. felis, the cat flea, in canines and felines; the optimal dose set for canines is reported to be 30 mg/kg. Ha Scope Triangle 1 Pryriproxifen 10 % SC Lano Sumitomo Chem the insect system... 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As natural product-based, and Natroba names Cyclio and Exil Flea Free TwinSpot ( Emax ) spinosoids! Suspension is used to treat head lice by Parapro Llc or near the base of plants by! Resembles a GABA antagonist and is included in one NDA personal medication records reproductive in. 'S dosage form is suspension and is comparable to the effect of on... 'S widespread commercial launch was deferred, awaiting final MRL or tolerance approvals in a few remain… Brand.
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