Found inside – Page 530BOX 53.5 n Principal Steps of Nitroprusside Metabolism 1. Cyanide ions (CN–) are liberated from nitroprusside by red blood cell or endothelial cell ... Found inside – Page 352Sodium nitroprusside and intravenous diazoxide are reserved for the management of ... Cyanide ions are a by-product of nitroprusside metabolism. Found inside – Page 148Ivankovich, A. D., Miletich, D. J., and Tinker, J. H. (1978) Sodium nitroprusside: Metabolism and general considerations. Internat Anesthesiol Clin, 16, ... Found insideThese characteristics make sodium nitroprusside a first-line drug for the treatment of ... Cyanide derived from sodium nitroprusside metabolism also. Found inside – Page 572Place opaque covering over infusion container because drug is metabolized by ... (which forms during nitroprusside metabolism) at least every 72 hours; ... Found inside – Page 55Metabolism Hydralazine Nitroprusside has a plasma half - life of less than 10 minutes and on contact with red blood cells , it rapidly forms methemoglobin ... Found inside – Page 439Other side effects relate to the metabolism of nitroprusside. The drug is metabolized in the blood to cyanide, which is further metabolized to thiocyanate, ... Found inside – Page 798Absorption, Metabolism, and Excretion. Sodium nitroprusside is an unstable molecule that decomposes under strongly alkaline conditions and when exposed to light. The drug must be given by continuous intravenous infuSion to be effective. Found inside – Page 30Nitroprusside Effects on Clearances Over Long Periods of Exchanges . ... This suggests either negligible nitroprusside absorption in metabolism or excretion ... Found inside – Page 345Because nitroprusside is metabolized rapidly to cyanogen ( cyanide radical ) and then to thiocyanate in the liver , care must be taken to ensure that the ... Found inside – Page 218Hersey SL, O'Dell NE, Lowe S. Nicardipine versus nitroprusside for controlled ... Effect of hypothermic cardiopulmonary bypass on nitroprusside metabolism. Found inside – Page 809Surg Neurol 6: 71-80, 1976 2) Brown FD, Crockard HA, Johns LM, Mullan S: The effects of sodium nitroprusside and trimethaphan ... Greenbaum R: Cerebral blood flow and metabolism during hypotension induced with sodium nitroprusside ... Found inside – Page 411... CYTOCHROME (Kidney) CO OXIDASE (CO) CN– THIOCYANATEOXIDASE THIOCYANATE Urine (Blood) FIG 20-9 Primary Pathways of Sodium Nitroprusside Metabolism. Found inside – Page 364With cytochrome oxidase inactivated, tissue anoxia, anaerobic metabolism, ... requiring larger and larger doses of nitroprusside to maintain BP control). Found inside – Page 1003Nitroprusside is metabolized to thiocyanate, and cyanide is an intermediary in its metabolism. Consequently, cyanide and thiocyanate toxicity must be ... Found inside – Page 11830... reductive in metabolism Overgaard J. Oncol tumors . mediated by intercellular communication . Bánhegyi G , et 6 ( 10-11 ) : 509-18 nitroprusside by ... Found inside – Page 390N Keyword section Key PointsDiscussion Nitroprusside Toxicity: Dx ... by tachyphylaxis to nitroprusside, cardiac dysrhythmias, metabolic acidosis, ... Found inside – Page 227Nitroprusside is metabolized rapidly ( half - life of minutes ) and requires continuous infusion to maintain its hypotensive action . Found inside – Page 264i.v. Nitroprusside Cyanmethaemoglobin + Free cyanide Thiocyanate Liver 7-day half-time Urine Figure 6.3 Nitroprusside metabolism. Found inside – Page 1165Ition , tremia or in patients receiving sodium thiosulfate , either alone or concomitantly When IV sodium nitroprusside is used for controlled hypotension duood with sodium nitroprusside to accelerate the metabolism of cyanogen . Found inside – Page 22CBF and CMRO2 (mean + SEM) during hypotension induced with sodium nitroprusside and deep halothane anesthesia. Hypotensive Sodium agent Halothane ... Found inside – Page 240Nitroprusside is metabolized rapidly (half-life of minutes) and requires continuous infusion to maintain its hypotensive action. Sodium nitroprusside exerts ... Found inside – Page 358nitroprusside and intravenous diazoxide are reserved for the management of hypertensive ... Cyanide ions are a by-product of nitroprusside metabolism. Found inside – Page 266Suspected sodium nitroprusside - induced cyanide intoxication . ... metabolism / CEREBROVASCULAR CIRCULATION , drug effects / * FERRICYANIDES ... Found inside – Page 203Agent Dose Metabolism ↑ Arterial Tone Nitroprusside 0.5–10 μg/kg/min (bolus 1–2 μg/kg) NTP: red blood cells Cyanide ions: hepatic Thiocyanate: renal ... Found insideCoronary Microvascular Obstruction in Acute Myocardial Infarction: From Mechanisms to Treatment provides a comprehensive understanding of the phenomenon of coronary microvascular obstruction (CMVO) that is the main limitation of reperfusion ... Found inside – Page 255Nitroprusside metabolism results in the release of cyanide anions in vivo. Cyanide is generally rapidly metabolized by hepatic rhodanase to thiocyanate ... Found inside – Page 343by-product of nitroprusside metabolism. Cyanide and thiocyanate toxicity are seen clinically when nitroprusside is used at high dosages for long periods of ... Found inside – Page 449Cyanide ions are a byproduct of sodium nitroprusside metabolism. Cyanide and thiocyanate toxicity are seen clinically when sodium nitroprusside is used at ... Found inside – Page 406Free cyanide radicals generated by the metabolism or breakdown of sodium nitroprusside are metabolized by one of the following four potential mechanisms: 1. Found inside – Page 100The major side effect of the drug is the accumulation of cyanide as a result of the nitroprusside metabolism . This can be monitored by looking for metabolic acidosis , since cyanide poisons the electron transport systems and leads to anerobic ... Found inside – Page 480Because of these qualities, nitroprusside is a drug of choice for treating hypertensive emergencies. Cardiovascular Effects In contrast to ... to that of nitroglycerin. Metabolism As shown in Figure 39–1, nitroprusside contains five cyanide groups, ... Found inside – Page 263Nitroprusside is sensitive to light and must be protected with an opaque covering to ... which are metabolites of nitroprusside metabolism, may cause toxic ... Found inside – Page 220Ivankovich AD, Miletich DJ, Tinker Sodium nitroprusside: metabolism and general considerations. Int Anesthesiol Clin 1978;1621-29. Found inside – Page 508... step of nitroprusside metabolism. Nitric oxide, the active component, is released next. Both reactions take place in smooth muscle. Found inside – Page 192Nitroprusside was discovered in 1850 and introduced into clinical use in 1974.98 ... Metabolism Nitroprusside metabolism occurs in a series of steps (Fig. Found inside – Page 527This mechanism is similar to that of nitroglycerin. Metabolism As shown in Figure 46–1, nitroprusside contains five cyanide groups, ... Found inside – Page 1220Prolonged infusion of nitroprusside may be associated with a toxic psychosis from accumulation of thiocyanate , the major end - product of nitroprusside metabolism . Thiocyanate is excreted by the kidneys , and this complication is particularly ... Found inside – Page 105The cyanide anion can combine with the enzyme cytochrome C to inhibit aerobic metabolism . The cyanide formed as a by - product of nitroprusside metabolism can then be converted to thiocyanate through the action of the liver enzyme ... Found inside – Page 958Nitroprusside metabolism produces dose-related cyanide, which can be lethal. □ At infusions above 2 mcg/kg/min, cyanide ion is generated faster than the ... Found inside – Page 30Nitroprusside Effects on Clearances Over Long Periods of Exchanges . ... This suggests either negligible nitroprusside absorption in metabolism or excretion ... Found inside – Page 976Nitroprusside metabolism produces dose-related cyanide, which can be lethal. □ At infusions above 2 mcg/kg/min, cyanide ion is generated faster than the ... Found inside – Page 442Iron metabolism and its disorders . Malnutrition , fertility and family planning . Sen Gupta PN . Sodium nitroprusside : metabolism and general ... Found inside – Page 666Other potential adverse effects may result from its metabolism . Sodium nitroprusside binds quickly to the sulfhydryl groups on hemoglobin , oxidizing it to ... 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