This work has developed and utilized methods for combining genome-scale ChIP- and RNA-sequencing data to describe direct and indirect transcriptional regulation, and has added to the definition of transcription factor networks in N. crassa. Using the novel analyses abilities of SeqUnwinder, we make important contributions towards understanding TF binding in neuronal reprogramming systems. This book is intended for scientists and medical researchers especially who are interested in the relationships between transcription and human diseases. This volume consists of an introductory chapter and 14 chapters, divided into 4 parts. Despite the advent of high throughput genomics technology and the wealth of data characterizing transcription that followed, it remains difficult to relate genomic sequence to transcriptional activity. Abstract: Transcriptional regulation is a critical mediator of many normal cellular processes as well as disease progression. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. Plant Transcription Factors: Evolutionary, Structural and Functional Aspects is the only publication that provides a comprehensive compilation of plant transcription factor families and their complex roles in plant biology. Found insideThis book provides some insights into aspects of yeast science and biotechnology less frequently addressed in the literature but nonetheless decisive to improve knowledge and, accordingly, boost up yeast-based innovation. The novel method in identifying DNA-binding proteins is particularly useful as this technique allows identification of protein seen in EMSA without the need of extensive identification process. This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand the key concepts to expanding their work. Adding to its utility, the work provides short entries that briefly define key terms, and a guide to additional reading and relevant websites for further study. Many of the entries include figures to explain difficult concepts. Found insideMechanisms of Transcription presents a unique perspective on the fundamental processes of transcription. A collection of distinguished authors draws together the underlying mechanisms involved in the process of transcription. Chapter 1 serves as a general introduction into eukaryotic transcription regulation and describes the role of enhancers and transcription factors. Chapters 2 - 4 describe the experimental work of this thesis. Found insideThis book, Huntington's Disease-Molecular Pathogenesis and Current Models, is planned to cover recent scientific achievements in understanding the cellular mechanisms of HD. The chapters provide comprehensive description of the key issues ... This book provides a reference for major aspects of transcription factor function, encompassing a general catalogue of known transcription factor classes, origins and evolution of specific transcription factor types, methods for studying ... A strength of Concepts of Biology is that instructors can customize the book, adapting it to the approach that works best in their classroom. Changes in transcriptional regulatory networks are thought to underlie most morphological change observed across taxa, but the general principles of how such networks change and why remain unknown. Cells require their genetic information to be expressed appropriately; the ability to modulate gene expression in a proper spatiotemporal response to external and internal signals is central to survival. Survival of cells and organisms requires that each of thousands of genes is expressed at the correct time in development, in the correct tissue, and under the correct conditions. Found insideIts approachable style makes the book accessible for introductory students and educated laypersons. Evolution since Coding is suitable to supplement college courses that mix computers, evolution, and biology from freshman to senior level. A much-needed guide through the overwhelming amount of literature in the field. Comprehensive and detailed, this book combines background information with the most recentinsights. The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. This volume attempts to present some of the recent work on regulation of gene expression in eukaryotic cells. The human genome is regulated at several levels ranging from small chemical modifications of DNA bases, to higher-order chromosome organization in the nucleus. Found insideThis book focuses on the transcriptional and post-transcriptional gene regulations and presents a detailed portrait of many novel aspects related to highlighting the importance of key TFs in some vital biological processes, the role of ... During transcriptional regulation, transcription factor proteins bind to particular sites in the genome in order to switch genes on or off. Cell populations typically exhibit binary or graded transcriptional responses to external stimuli. Transcription factor interactions with DNA have been hypothesized to account for both of these scenarios. Found insideContents include: * What to expect from the different types of medical interview * Common medical interview questions and how best to answer them * Current information on the most likely knowledge-based questions * How to prepare for ... The information about how, when, and where are produced the proteins has been one of the major challenge in molecular biology. This is the first in a series of volumes concerning the properties of the eukaryotic nucleus. It lacks the classical uA-TFE3(CBF)-uB core array of binding motifs seen within mammalian IgH Eu enchacers. To determine the functional DNA binding motifs required for activity within this enhancer, a series of mutant enchacers was created. ChIP-Seq is a technology for detecting in vivo transcription factor binding sites or histone modification sites on a genome wide scale. This book has fundamental theoretical and practical aspects of data analysis, useful for beginners and experienced researchers that are looking for a recipe or an analysis approach. At the very least, you would think that if I was going to write a textbook, I should write one in an area that really needs one instead of a subject that already has multiple excellent and definitive books. So, why write this book, then? Found inside – Page iiTherefore, the focus of this book is the description of the post-genome understanding of gene regulation. This remains a distant goal, mainly due to the lack of a high-throughput, in vivo method to study protein-DNA interactions. To fill this gap, I developed transposon "Calling Cards" for DNA-binding proteins. Since publication of the Fourth Edition, there have been major advances, notably in the areas of chromatin remodeling and genome-scale analyses. The polyomavirus origin of DNA replication, a model for eukaryotic DNA replication, is comprised of the core origin and two auxiliary sequences, which enhance replication. Found insideThis volume provides an up-to-date ac count of present reports concerning E2F as well as a framework for future investigations. E2F activity requires heterodimerization of two partners. Throughout this work the reader is witness to scientific discovery and debate centered on such common concerns as the dramatic and transforming effect of computers on scientists' thinking and research; the development of more cross ... Due to that at present, the majority of diseases are associated with alterations in oxidative stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes; knowing how this transcriptional factor functions and is ... This volume has a strong focus on homo-oligomerization, which is surprisingly common. Found insideAddressing the various complexities of transcriptional regulation, this book includes chapters on cross talk and central regulation, regulatory networks, the role of DOF, WRKY and NAC transcription factors, zinc finger proteins, CRISPR/CAS9 ... Transcription factors (TFs) are proteins that control the rate of transcription. This volume provides an overview of experimental procedures and state-of art methods to investigate FOXOs. Three different feature extraction methods are used based on k-mer representations, counts of known motifs and a new model called the skip-gram model, which has become very popular in the analysis of text. Unique perspective on the fundamental processes of transcription present some of the work... First in a series of mutant enchacers was created relationships between transcription and human.... Genome in order to switch genes on or off factors ( TFs ) are proteins that the... 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